Clinical Trial: NCT01896999
Brentuximab Vedotin and Nivolumab With or Without Ipilimumab in Treating Patients With Relapsed or Refractory Hodgkin Lymphoma
Status:
ACTIVE NOT RECRUITINGPhase:
Phase 1| Lead Sponsor: | National Cancer Institute (NCI) |
| Information Provided By: | National Cancer Institute (NCI) |
| Last Update Posted: | 2026-09-29 |
Study Overview
Brief Summary
This phase I/II trial studies the side effects and best dose of ipilimumab and nivolumab when given together with brentuximab vedotin, and how well they work in treating patients with Hodgkin lymphoma that has returned after a period of improvement (recurrent) or has not responded to previous treatment (refractory). Immunotherapy with monoclonal antibodies, such as ipilimumab and nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of cancer cells to grow and spread. Brentuximab vedotin is a monoclonal antibody, brentuximab, linked to a toxic agent called vedotin. Brentuximab attaches to CD30 positive cancer cells in a targeted way and delivers vedotin to kill them. It is not known whether giving brentuximab vedotin and nivolumab with or without ipilimumab may kill more cancer cells.
Official Title
Conditions
Intervention / Treatment
- Procedure: Biopsy Procedure
- Procedure: Biospecimen Collection
- Drug: Brentuximab Vedotin
- Procedure: Computed Tomography
- Biological: Ipilimumab
- Biological: Nivolumab
- Procedure: Positron Emission Tomography
Other Study ID Numbers
- NCI-2013-01275
- NCI-2013-01275
- E4412
- S14-00011
- E4412
- E4412
- U10CA180820
- U24CA196172
Start Date (Actual)
Primary Completion Date (Estimated)
Study Completion Date (Estimated)
Enrollment (Estimated)
Study Type
Phase
| Lead Sponsor: | National Cancer Institute (NCI) |
| Information Provided By: | National Cancer Institute (NCI) |
| Last Update Posted: | 2026-09-29 |
Study Overview
Brief Summary
This phase I/II trial studies the side effects and best dose of ipilimumab and nivolumab when given together with brentuximab vedotin, and how well they work in treating patients with Hodgkin lymphoma that has returned after a period of improvement (recurrent) or has not responded to previous treatment (refractory). Immunotherapy with monoclonal antibodies, such as ipilimumab and nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of cancer cells to grow and spread. Brentuximab vedotin is a monoclonal antibody, brentuximab, linked to a toxic agent called vedotin. Brentuximab attaches to CD30 positive cancer cells in a targeted way and delivers vedotin to kill them. It is not known whether giving brentuximab vedotin and nivolumab with or without ipilimumab may kill more cancer cells.
Official Title
Conditions
Intervention / Treatment
- Procedure: Biopsy Procedure
- Procedure: Biospecimen Collection
- Drug: Brentuximab Vedotin
- Procedure: Computed Tomography
- Biological: Ipilimumab
- Biological: Nivolumab
- Procedure: Positron Emission Tomography
Other Study ID Numbers
- NCI-2013-01275
- NCI-2013-01275
- E4412
- S14-00011
- E4412
- E4412
- U10CA180820
- U24CA196172