OncRef

Clinical Trial: NCT01949129

Allogeneic Stem Cell Transplantation for Children and Adolescents With Acute Lymphoblastic Leukaemia

Status:

RECRUITING

Phase:

Phase 2

Lead Sponsor:St. Anna Kinderkrebsforschung
Information Provided By:St. Anna Kinderkrebsforschung
Last Update Posted:2026-09-04

Study Overview

Brief Summary

The ALL SCTped 2012 FORUM is a multinational, multi-centre, controlled, prospective phase III study for the therapy and therapy optimisation for children and adolescents with ALL in complete morphological remission (CR, less than 5% bone marrow blasts, no blasts in cerebrospinal fluid, no other extramedullary leukemia), who have an indication for HSCT with a myeloablative conditioning regimen.

The stratification of patients in first and following remissions according to the individual transplantation modalities rests upon an indication for allogeneic HSCT and the availability of a suitable donor within the individual transplantation groups.

Official Title

Allogeneic Stem Cell Transplantation for Children and Adolescents With Acute Lymphoblastic Leukaemia

Conditions

Acute Lymphoblastic Leukaemia

Intervention / Treatment

  • Drug: VP16
  • Radiation: TBI
  • Drug: Thiotepa
  • Drug: Treosulfan
  • Drug: Fludarabine
  • Drug: Busulfan
  • Drug: ATG Thymoglobulin
  • Drug: Cyclophosphamide
  • Drug: Grafalon

Other Study ID Numbers

  • ALL SCTped FORUM 2012

Start Date

2013-04

Primary Completion Date (Estimated)

2030-06-01

Study Completion Date (Estimated)

2030-06-01

Enrollment (Estimated)

1800

Study Type

Interventional

Phase

Phase 2, Phase 3