OncRef

Clinical Trial: NCT02764541

Palbociclib and Endocrine Therapy for LObular Breast Cancer Preoperative Study (PELOPS)

Status:

ACTIVE NOT RECRUITING

Phase:

Phase 2

Lead Sponsor:Dana-Farber Cancer Institute
Information Provided By:Dana-Farber Cancer Institute
Last Update Posted:2026-06-23

Study Overview

Brief Summary

This research study is evaluating how well Breast Cancer responds to preoperative treatment with Endocrine treatment in combination with a drug called Palbociclib or Endocrine treatment alone as possible treatments for Hormone Receptor Positive Breast Cancer.

Official Title

Palbociclib and Endocrine Therapy for LObular Breast Cancer Preoperative Study (PELOPS): A Randomized Phase II Study of Palbociclib With Letrozole Versus Letrozole Alone for Invasive Lobular Carcinoma and Invasive Ductal Carcinoma

Conditions

Breast Cancer

Intervention / Treatment

  • Drug: Letrozole
  • Drug: Tamoxifen
  • Drug: Palbociclib
  • Drug: Endocrine Therapy

Other Study ID Numbers

  • 16-052

Start Date (Actual)

2016-05-24

Primary Completion Date (Actual)

2022-02

Study Completion Date (Estimated)

2031-04

Enrollment (Actual)

195

Study Type

Interventional

Phase

Phase 2