OncRef

Clinical Trial: NCT03600701

Atezolizumab and Cobimetinib in Treating Patients With Metastatic, Recurrent, or Refractory Non-small Cell Lung Cancer

Status:

ACTIVE NOT RECRUITING

Phase:

Phase 2

Lead Sponsor:National Cancer Institute (NCI)
Information Provided By:National Cancer Institute (NCI)
Last Update Posted:2026-09-01

Study Overview

Brief Summary

This phase II trial studies how well atezolizumab and cobimetinib work in treating patients with non-small cell lung cancer that has spread from where it first started (primary site) to other places in the body (metastatic), has come back (recurrent), or does not respond to treatment (refractory). Immunotherapy with monoclonal antibodies, such as atezolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Cobimetinib is used in patients whose cancer has a mutated (changed) form of a gene called BRAF. It is in a class of medications called kinase inhibitors. It works by blocking the action of an abnormal protein that signals cancer cells to multiply. This helps slow or stop the spread of cancer cells. Giving atezolizumab and cobimetinib may work better in treating patients with non-small cell lung cancer.

Official Title

A Phase 2 Study of Atezolizumab and Cobimetinib in PD-1/PD-L1 Inhibitor Resistant or Refractory Non-Small Cell Lung Cancer

Conditions

Metastatic Lung Non-Small Cell Carcinoma, Recurrent Lung Non-Small Cell Carcinoma, Refractory Lung Non-Small Cell Carcinoma, Stage IV Lung Cancer AJCC v8

Intervention / Treatment

  • Drug: Atezolizumab
  • Procedure: Biopsy Procedure
  • Procedure: Biospecimen Collection
  • Drug: Cobimetinib
  • Procedure: Computed Tomography
  • Procedure: Magnetic Resonance Imaging

Other Study ID Numbers

  • NCI-2017-01812
  • NCI-2017-01812
  • 10166
  • 10166
  • UM1CA186691

Start Date (Actual)

2018-11-29

Primary Completion Date (Actual)

2025-07-14

Study Completion Date (Estimated)

2026-10-03

Enrollment (Actual)

53

Study Type

Interventional

Phase

Phase 2