Clinical Trial: NCT03955783
Venetoclax and Selinexor in Treating Patients with Relapsed or Refractory High Risk Hematologic Malignancies
Status:
COMPLETEDPhase:
Phase 1| Lead Sponsor: | Sanjay Mohan |
| Information Provided By: | Vanderbilt-Ingram Cancer Center |
| Last Update Posted: | 2024-10-26 |
Study Overview
Brief Summary
This phase Ib trial studies the toxicity and dosing of venetoclax in combination with selinexor, and how well the combination works in treatment of patients with high risk hematologic malignancies such as diffuse large B-cell lymphoma and acute myeloid leukemia that has come back (recurrent) or does not respond to initial treatment (refractory). Venetoclax functions by inhibiting a protein in the body called bcl-2, which is involved in slowing down the normal process by which old cells in the body are cleared (called apoptosis). Selinexor functions by trapping "tumor suppressing proteins" within the cell and causing the cancer cells to die or stop growing. This study examines the effects, if any, of selinexor and venetoclax on high risk hematologic malignancies and on the body, including any side-effects.
Official Title
Conditions
Intervention / Treatment
- Drug: Venetoclax
- Drug: Selinexor
Other Study ID Numbers
- VICC HEM 1755
- NCI-2019-02953
Start Date (Actual)
Primary Completion Date (Actual)
Study Completion Date (Actual)
Enrollment (Actual)
Study Type
Phase
| Lead Sponsor: | Sanjay Mohan |
| Information Provided By: | Vanderbilt-Ingram Cancer Center |
| Last Update Posted: | 2024-10-26 |
Study Overview
Brief Summary
This phase Ib trial studies the toxicity and dosing of venetoclax in combination with selinexor, and how well the combination works in treatment of patients with high risk hematologic malignancies such as diffuse large B-cell lymphoma and acute myeloid leukemia that has come back (recurrent) or does not respond to initial treatment (refractory). Venetoclax functions by inhibiting a protein in the body called bcl-2, which is involved in slowing down the normal process by which old cells in the body are cleared (called apoptosis). Selinexor functions by trapping "tumor suppressing proteins" within the cell and causing the cancer cells to die or stop growing. This study examines the effects, if any, of selinexor and venetoclax on high risk hematologic malignancies and on the body, including any side-effects.
Official Title
Conditions
Intervention / Treatment
- Drug: Venetoclax
- Drug: Selinexor
Other Study ID Numbers
- VICC HEM 1755
- NCI-2019-02953