OncRef

Clinical Trial: NCT04392505

Durvalumab(MEDI4736) After chemoRadioTherapy(DART) for NSCLC-a Translational and Biomarker Study

Status:

ACTIVE NOT RECRUITING

Phase:

Phase 2

Lead Sponsor:Oslo University Hospital
Information Provided By:Oslo University Hospital
Last Update Posted:2024-02-29

Study Overview

Brief Summary

The main aim is to identify and describe biomarkers in different sample types related to chemoradiation followed by durvalumab treatment for stage III PD-L1 negative and positive non-small cell lung cancer (NSCLC) patients' eligible for curatively intended chemoradiation.

The hypothesis is that clinical differences in course of disease reflect underlying biological characteristics.

Official Title

Durvalumab (MEDI4736) After chemoRadioTherapy (DART) for NSCLC Patients - a Phase II Translational and Biomarker Study Investigating PDL1 Positive and Negative Patients

Conditions

Cancer, Non Small Cell Lung Cancer, Non Small Cell Lung Cancer Stage III, NSCLC, NSCLC, Stage III

Intervention / Treatment

  • Drug: Durvalumab Injection

Other Study ID Numbers

  • DART

Start Date (Actual)

2020-05-11

Primary Completion Date (Estimated)

2025-05-01

Study Completion Date (Estimated)

2033-05-01

Enrollment (Estimated)

100

Study Type

Interventional

Phase

Phase 2