OncRef

Clinical Trial: NCT04573231

Evaluation of PSMA in HER2- AR+ Metastatic Breast Cancer

Status:

COMPLETED

Phase:

Phase 2

Lead Sponsor:University of Wisconsin, Madison
Information Provided By:University of Wisconsin, Madison
Last Update Posted:2026-09-28

Study Overview

Brief Summary

The purpose of this research is to determine the expression of prostate specific membrane antigen (PSMA) in human epidermal growth factor receptor 2 (HER2)-negative, androgen receptor (AR)-positive metastatic breast cancer, and to determine its role in resistance to the anti-androgen, bicalutamide. The investigators hypothesize that PSMA expression will correlate with resistance to anti-androgen therapies, as has been documented in prostate cancer, and this can be used to select patients most likely to benefit from these therapies in future clinical trials. 15 people with HER2-negative, AR-positive metastatic breast cancer will be enrolled and be on study for about 3 days.

Official Title

Evaluation of Prostate Specific Membrane Antigen (PSMA) in HER2-negative, Androgen Receptor (AR)-Positive Metastatic Breast Cancer With 18F-DCFPyL PSMA-based PET/CT

Conditions

Breast Cancer, HER2-negative Breast Cancer, Metastatic Breast Cancer

Intervention / Treatment

  • Drug: 18F-DCFPyL

Other Study ID Numbers

  • 2020-0949
  • A539300
  • SMPH/RADIOLOGY/RADIOLOGY
  • Protocol Version 12/12/2025
  • NCI-2020-07434
  • 2020-0949

Start Date (Actual)

2021-05-24

Primary Completion Date (Actual)

2026-08-31

Study Completion Date (Actual)

2026-08-31

Enrollment (Actual)

13

Study Type

Interventional

Phase

Phase 2