Clinical Trial: NCT04573231
Evaluation of PSMA in HER2- AR+ Metastatic Breast Cancer
Status:
COMPLETEDPhase:
Phase 2| Lead Sponsor: | University of Wisconsin, Madison |
| Information Provided By: | University of Wisconsin, Madison |
| Last Update Posted: | 2026-09-28 |
Study Overview
Brief Summary
The purpose of this research is to determine the expression of prostate specific membrane antigen (PSMA) in human epidermal growth factor receptor 2 (HER2)-negative, androgen receptor (AR)-positive metastatic breast cancer, and to determine its role in resistance to the anti-androgen, bicalutamide. The investigators hypothesize that PSMA expression will correlate with resistance to anti-androgen therapies, as has been documented in prostate cancer, and this can be used to select patients most likely to benefit from these therapies in future clinical trials. 15 people with HER2-negative, AR-positive metastatic breast cancer will be enrolled and be on study for about 3 days.
Official Title
Conditions
Intervention / Treatment
- Drug: 18F-DCFPyL
Other Study ID Numbers
- 2020-0949
- A539300
- SMPH/RADIOLOGY/RADIOLOGY
- Protocol Version 12/12/2025
- NCI-2020-07434
- 2020-0949
Start Date (Actual)
Primary Completion Date (Actual)
Study Completion Date (Actual)
Enrollment (Actual)
Study Type
Phase
| Lead Sponsor: | University of Wisconsin, Madison |
| Information Provided By: | University of Wisconsin, Madison |
| Last Update Posted: | 2026-09-28 |
Study Overview
Brief Summary
The purpose of this research is to determine the expression of prostate specific membrane antigen (PSMA) in human epidermal growth factor receptor 2 (HER2)-negative, androgen receptor (AR)-positive metastatic breast cancer, and to determine its role in resistance to the anti-androgen, bicalutamide. The investigators hypothesize that PSMA expression will correlate with resistance to anti-androgen therapies, as has been documented in prostate cancer, and this can be used to select patients most likely to benefit from these therapies in future clinical trials. 15 people with HER2-negative, AR-positive metastatic breast cancer will be enrolled and be on study for about 3 days.
Official Title
Conditions
Intervention / Treatment
- Drug: 18F-DCFPyL
Other Study ID Numbers
- 2020-0949
- A539300
- SMPH/RADIOLOGY/RADIOLOGY
- Protocol Version 12/12/2025
- NCI-2020-07434
- 2020-0949