OncRef

Clinical Trial: NCT05806138

A Study of Vericiguat in People With Breast Cancer and Cancer Therapy-Related Cardiac Dysfunction

Status:

ACTIVE NOT RECRUITING

Phase:

Phase 2

Lead Sponsor:Memorial Sloan Kettering Cancer Center
Information Provided By:Memorial Sloan Kettering Cancer Center
Last Update Posted:2026-08-03

Study Overview

Brief Summary

The purpose of this study is to find out if adding vericiguat to standard treatment for cancer therapy related cardiac dysfunction (CTRCD) is more effective than standard treatment alone. The addition of vericiguat to the usual treatment could help improve cardiac function, but it could also cause side effects. This study will help researchers find out whether this different treatment is better, the same as, or worse than the usual approach.

Official Title

A Randomized Controlled Trial of the Soluble Guanylate Cyclase Stimulator Vericiguat in Patients With Breast Cancer and Cancer Therapy-Related Cardiac Dysfunction (ELEVATE)

Conditions

Breast Cancer, Cardiac Dysfunction

Intervention / Treatment

  • Drug: Vericiguat
  • Other: Optimal medical therapy

Other Study ID Numbers

  • 23-050

Start Date (Actual)

2023-07-17

Primary Completion Date (Estimated)

2028-07-17

Study Completion Date (Estimated)

2028-07-17

Enrollment (Actual)

21

Study Type

Interventional

Phase

Phase 2