OncRef

Clinical Trial: NCT06052826

Geriatric Assessment Guided Interventions to Accelerate Functional Recovery After CAR-T Therapy for Patients 60 Years and Older With B-cell Non-Hodgkin Lymphoma or Multiple Myeloma, GOCART Study

Status:

RECRUITING

Phase:

Phase 2

Lead Sponsor:City of Hope Medical Center
Information Provided By:City of Hope Medical Center
Last Update Posted:2026-09-25

Study Overview

Brief Summary

This clinical trial compares the effectiveness of geriatric assessment (GA) guided interventions to accelerate functional recovery after chimeric antigen receptor T-cell (CAR-T) therapy compared to standard of care (SOC) in patients 60 years and older with B-cell non-Hodgkin lymphoma (NHL) or multiple myeloma (MM). A large number of patients diagnosed with cancer are over the age of 60, yet most cancer treatments are developed for younger patients. Therefore, older patients may be less likely to be offered stronger treatments, such as CAR-T therapy, due to possible side effects. Geriatric assessment is a multi-dimensional health assessment tool combining patient reported and objective measures covering physical function, mental processes (cognitive), and nutrition. Pre-treatment assessments may identify weaknesses in older adults and may guide interventions for physical therapy, cognitive changes and nutrition to decrease CAR-T therapy side effects and improve care in older adults with NHL or MM.

Official Title

Geriatric (G) Assessment Guided Optimization (O) to Accelerate Functional Recovery After Chimeric Antigen Receptor T-Cell (CAR-T) Therapy for Patients 60 Years and Older With B-Cell Non-Hodgkin Lymphoma or Multiple Myeloma (GOCART)

Conditions

B-Cell Non-Hodgkin Lymphoma, Multiple Myeloma

Intervention / Treatment

  • Other: Best Practice
  • Other: Cognitive Intervention
  • Other: Comprehensive Geriatric Assessment
  • Other: Nutritional Intervention
  • Procedure: Physical Therapy
  • Other: Questionnaire Administration

Other Study ID Numbers

  • 22422
  • NCI-2023-04359
  • 22422
  • P30CA033572

Start Date (Actual)

2023-06-23

Primary Completion Date (Estimated)

2026-10-05

Study Completion Date (Estimated)

2026-10-05

Enrollment (Estimated)

164

Study Type

Interventional

Phase

Phase 2